Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide

The B.1.1.7 variant of the SARS-CoV-2 virus shows enhanced infectiousness over the wild type virus, leading to increasing patient numbers in affected areas. Amino acid exchanges within the SARS-CoV-2 spike protein variant of B.1.1.7 affect inter-monomeric contact sites within the trimer (A570D and D...

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Detalles Bibliográficos
Autores principales: Socher, Eileen, Conrad, Marcus, Heger, Lukas, Paulsen, Friedrich, Sticht, Heinrich, Zunke, Friederike, Arnold, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151884/
https://www.ncbi.nlm.nih.gov/pubmed/34066729
http://dx.doi.org/10.3390/biomedicines9050525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151884/
https://www.ncbi.nlm.nih.gov/pubmed/34066729
http://dx.doi.org/10.3390/biomedicines9050525

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