High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice

SIMPLE SUMMARY: Targeting topoisomerases has been widely used as anticancer therapeutics. Exposure to high temperature (hyperthermia) protects cells from the cytotoxic effect of topoisomerase-targeting therapeutics, yet the mechanism remains unknown. Here, we report that hyperthermia inhibits the nu...

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Detalles Bibliográficos
Autores principales: Ashour, Mohamed E., Allam, Walaa, Elsayed, Waheba, Atteya, Reham, Elserafy, Menattallah, Magdeldin, Sameh, Hassan, Mohamed K., El-Khamisy, Sherif F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151962/
https://www.ncbi.nlm.nih.gov/pubmed/34065967
http://dx.doi.org/10.3390/cancers13102315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151962/
https://www.ncbi.nlm.nih.gov/pubmed/34065967
http://dx.doi.org/10.3390/cancers13102315

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