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Creating a ‘Molecular Band-Aid’; Blocking an Exposed Protease Target Site in Desmoplakin

Desmoplakin (DSP) is a large (~260 kDa) protein found in the desmosome, a subcellular complex that links the cytoskeleton of one cell to its neighbor. A mutation ‘hot-spot’ within the NH(2)-terminal third of the DSP protein (specifically, residues 299–515) is associated with both cardiomyopathies an...

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Detalles Bibliográficos
Autores principales: Hoover, Catherine A., Ott, Kendahl L., Manring, Heather R., Dew, Trevor, Borzok, Maegen A., Wright, Nathan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151963/
https://www.ncbi.nlm.nih.gov/pubmed/34065787
http://dx.doi.org/10.3390/jpm11050401