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Creating a ‘Molecular Band-Aid’; Blocking an Exposed Protease Target Site in Desmoplakin
Desmoplakin (DSP) is a large (~260 kDa) protein found in the desmosome, a subcellular complex that links the cytoskeleton of one cell to its neighbor. A mutation ‘hot-spot’ within the NH(2)-terminal third of the DSP protein (specifically, residues 299–515) is associated with both cardiomyopathies an...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151963/ https://www.ncbi.nlm.nih.gov/pubmed/34065787 http://dx.doi.org/10.3390/jpm11050401 |