Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function

To characterize the mechanisms by which the highly conserved exocyst trafficking complex regulates eye physiology in zebrafish and mice, we focused on Exoc5 (also known as sec10), a central exocyst component. We analyzed both exoc5 zebrafish mutants and retinal pigmented epithelium (RPE)-specific Ex...

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Detalles Bibliográficos
Autores principales: Rohrer, Bärbel, Biswal, Manas R., Obert, Elisabeth, Dang, Yujing, Su, Yanhui, Zuo, Xiaofeng, Fogelgren, Ben, Kondkar, Altaf A., Lobo, Glenn P., Lipschutz, Joshua H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151988/
https://www.ncbi.nlm.nih.gov/pubmed/34064901
http://dx.doi.org/10.3390/ijms22105083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151988/
https://www.ncbi.nlm.nih.gov/pubmed/34064901
http://dx.doi.org/10.3390/ijms22105083

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