New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells

Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin (3) and myxin (4) exhibit potent and hypoxia-selective cell death on MOLM-13 human AML cells, and that the N-oxide funct...

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Detalles Bibliográficos
Autores principales: Viktorsson, Elvar Örn, Aesoy, Reidun, Støa, Sindre, Lekve, Viola, Døskeland, Stein Ove, Herfindal, Lars, Rongved, Pål
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152588/
https://www.ncbi.nlm.nih.gov/pubmed/34124675
http://dx.doi.org/10.1039/d1md00020a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152588/
https://www.ncbi.nlm.nih.gov/pubmed/34124675
http://dx.doi.org/10.1039/d1md00020a

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