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Effects of sedimentation, microgravity, hydrodynamic mixing and air–water interface on α-synuclein amyloid formation

The formation of amyloid fibrils is a characterizing feature of a range of protein misfolding diseases, including Parkinson's disease. The propensity of native proteins to form such amyloid fibril, both in vitro and in vivo, is highly sensitive to the surrounding environment, which can alter th...

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Detalles Bibliográficos
Autores principales: Zhou, Jiangtao, Ruggeri, Francesco S., Zimmermann, Manuela R., Meisl, Georg, Longo, Giovanni, Sekatskii, Sergey K., Knowles, Tuomas P. J., Dietler, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152616/
https://www.ncbi.nlm.nih.gov/pubmed/34094057
http://dx.doi.org/10.1039/d0sc00281j