Thermodynamic consequences of Tyr to Trp mutations in the cation–π-mediated binding of trimethyllysine by the HP1 chromodomain

Evolution has converged on cation–π interactions for recognition of quaternary alkyl ammonium groups such as trimethyllysine (Kme3). While computational modelling indicates that Trp provides the strongest cation–π interaction of the native aromatic amino acids, there is limited corroborative data fr...

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Detalles Bibliográficos
Autores principales: Krone, Mackenzie W., Albanese, Katherine I., Leighton, Gage O., He, Cyndi Qixin, Lee, Ga Young, Garcia-Borràs, Marc, Guseman, Alex J., Williams, David C., Houk, K. N., Brustad, Eric M., Waters, Marcey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152637/
https://www.ncbi.nlm.nih.gov/pubmed/34109021
http://dx.doi.org/10.1039/d0sc00227e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152637/
https://www.ncbi.nlm.nih.gov/pubmed/34109021
http://dx.doi.org/10.1039/d0sc00227e

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