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Synthesis of secondary and tertiary amides without coupling agents from amines and potassium acyltrifluoroborates (KATs)

Although highly effective for most amide syntheses, the activation of carboxylic acids requires the use of problematic coupling reagents and is often poorly suited for challenging cases such as N-methyl amino acids. As an alternative to both secondary and tertiary amides, we report their convenient...

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Detalles Bibliográficos
Autores principales: Schuhmacher, Anne, Shiro, Tomoya, Ryan, Sarah J., Bode, Jeffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152719/
https://www.ncbi.nlm.nih.gov/pubmed/34094137
http://dx.doi.org/10.1039/d0sc01330g