Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands

The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthes...

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Detalles Bibliográficos
Autores principales: Coban, Tomris, Robertson, Cameron, Schwikkard, Sianne, Singer, Richard, LeGresley, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152782/
https://www.ncbi.nlm.nih.gov/pubmed/34124673
http://dx.doi.org/10.1039/d0md00428f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152782/
https://www.ncbi.nlm.nih.gov/pubmed/34124673
http://dx.doi.org/10.1039/d0md00428f

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