Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands

The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthes...

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Detalles Bibliográficos
Autores principales: Coban, Tomris, Robertson, Cameron, Schwikkard, Sianne, Singer, Richard, LeGresley, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152782/
https://www.ncbi.nlm.nih.gov/pubmed/34124673
http://dx.doi.org/10.1039/d0md00428f
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author Coban, Tomris
Robertson, Cameron
Schwikkard, Sianne
Singer, Richard
LeGresley, Adam
author_facet Coban, Tomris
Robertson, Cameron
Schwikkard, Sianne
Singer, Richard
LeGresley, Adam
author_sort Coban, Tomris
collection PubMed
description The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.
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spelling pubmed-81527822021-06-11 Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands Coban, Tomris Robertson, Cameron Schwikkard, Sianne Singer, Richard LeGresley, Adam RSC Med Chem Chemistry The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes. RSC 2021-03-26 /pmc/articles/PMC8152782/ /pubmed/34124673 http://dx.doi.org/10.1039/d0md00428f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Coban, Tomris
Robertson, Cameron
Schwikkard, Sianne
Singer, Richard
LeGresley, Adam
Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands
title Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands
title_full Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands
title_fullStr Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands
title_full_unstemmed Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands
title_short Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands
title_sort synthesis and evaluation of bis(imino)anthracene derivatives as g-quadruplex ligands
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152782/
https://www.ncbi.nlm.nih.gov/pubmed/34124673
http://dx.doi.org/10.1039/d0md00428f
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