Cargando…

Dynamic pH responsivity of triazole-based self-immolative linkers

Gating the release of chemical payloads in response to transient signals is an important feature of ‘smart’ delivery systems. Herein, we report a triazole-based self-immolative linker that can be reversibly paused or slowed and restarted throughout its elimination cascade in response to pH changes i...

Descripción completa

Detalles Bibliográficos
Autores principales: Roberts, Derrick A., Pilgrim, Ben S., Dell, Tristan N., Stevens, Molly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152797/
https://www.ncbi.nlm.nih.gov/pubmed/34094059
http://dx.doi.org/10.1039/d0sc00532k