Steric and stereoscopic disulfide construction for cross-linkage via N-dithiophthalimides

Disulfide bonds are a significant motif in life and drug-delivery systems. In particular, steric hindrance and stereoscopic disulfide linkers are closely associated with the stability of antibody–drug conjugates, which affects the potency, selectivity, and pharmacokinetics of drugs. However, limited...

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Detalles Bibliográficos
Autores principales: Gao, Wen-Chao, Tian, Jun, Shang, Yu-Zhu, Jiang, Xuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152801/
https://www.ncbi.nlm.nih.gov/pubmed/34122859
http://dx.doi.org/10.1039/d0sc01060j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152801/
https://www.ncbi.nlm.nih.gov/pubmed/34122859
http://dx.doi.org/10.1039/d0sc01060j

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