Inhibiting quinolone biosynthesis of Burkholderia

2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first known HmqD inhibitors. The most potent inhibito...

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Detalles Bibliográficos
Autores principales: Prothiwa, Michaela, Filz, Verena, Oehler, Sebastian, Böttcher, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153077/
https://www.ncbi.nlm.nih.gov/pubmed/34123319
http://dx.doi.org/10.1039/d0sc06167k
Descripción
Sumario:2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first known HmqD inhibitors. The most potent inhibitors quantitatively blocked quinolone production in Burkholderia cultures with single-digit micromolar efficacy.

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