Inhibiting quinolone biosynthesis of Burkholderia

2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first known HmqD inhibitors. The most potent inhibito...

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Detalles Bibliográficos
Autores principales: Prothiwa, Michaela, Filz, Verena, Oehler, Sebastian, Böttcher, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153077/
https://www.ncbi.nlm.nih.gov/pubmed/34123319
http://dx.doi.org/10.1039/d0sc06167k
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author Prothiwa, Michaela
Filz, Verena
Oehler, Sebastian
Böttcher, Thomas
author_facet Prothiwa, Michaela
Filz, Verena
Oehler, Sebastian
Böttcher, Thomas
author_sort Prothiwa, Michaela
collection PubMed
description 2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first known HmqD inhibitors. The most potent inhibitors quantitatively blocked quinolone production in Burkholderia cultures with single-digit micromolar efficacy.
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spelling pubmed-81530772021-06-11 Inhibiting quinolone biosynthesis of Burkholderia Prothiwa, Michaela Filz, Verena Oehler, Sebastian Böttcher, Thomas Chem Sci Chemistry 2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first known HmqD inhibitors. The most potent inhibitors quantitatively blocked quinolone production in Burkholderia cultures with single-digit micromolar efficacy. The Royal Society of Chemistry 2021-03-26 /pmc/articles/PMC8153077/ /pubmed/34123319 http://dx.doi.org/10.1039/d0sc06167k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Prothiwa, Michaela
Filz, Verena
Oehler, Sebastian
Böttcher, Thomas
Inhibiting quinolone biosynthesis of Burkholderia
title Inhibiting quinolone biosynthesis of Burkholderia
title_full Inhibiting quinolone biosynthesis of Burkholderia
title_fullStr Inhibiting quinolone biosynthesis of Burkholderia
title_full_unstemmed Inhibiting quinolone biosynthesis of Burkholderia
title_short Inhibiting quinolone biosynthesis of Burkholderia
title_sort inhibiting quinolone biosynthesis of burkholderia
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153077/
https://www.ncbi.nlm.nih.gov/pubmed/34123319
http://dx.doi.org/10.1039/d0sc06167k
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AT filzverena inhibitingquinolonebiosynthesisofburkholderia
AT oehlersebastian inhibitingquinolonebiosynthesisofburkholderia
AT bottcherthomas inhibitingquinolonebiosynthesisofburkholderia

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