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Inhibiting quinolone biosynthesis of Burkholderia
2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first known HmqD inhibitors. The most potent inhibito...
Autores principales: | Prothiwa, Michaela, Filz, Verena, Oehler, Sebastian, Böttcher, Thomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153077/ https://www.ncbi.nlm.nih.gov/pubmed/34123319 http://dx.doi.org/10.1039/d0sc06167k |
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