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Targeting structural features of viral genomes with a nano-sized supramolecular drug

RNA targeting is an exciting frontier for drug design. Intriguing targets include functional RNA structures in structurally-conserved untranslated regions (UTRs) of many lethal viruses. However, computational docking screens, valuable in protein structure targeting, fail for inherently flexible RNA....

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Detalles Bibliográficos
Autores principales: Melidis, Lazaros, Styles, Iain B., Hannon, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153246/
https://www.ncbi.nlm.nih.gov/pubmed/34123344
http://dx.doi.org/10.1039/d1sc00933h