Interleukin-17A Causes Osteoarthritis-Like Transcriptional Changes in Human Osteoarthritis-Derived Chondrocytes and Synovial Fibroblasts In Vitro

Increased interleukin (IL)-17A has been identified in joints affected by osteoarthritis (OA), but it is unclear how IL-17A, and its family members IL-17AF and IL-17F, can contribute to human OA pathophysiology. Therefore, we aimed to evaluate the gene expression and signalling pathway activation eff...

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Detalles Bibliográficos
Autores principales: Mimpen, Jolet Y., Baldwin, Mathew J., Cribbs, Adam P., Philpott, Martin, Carr, Andrew J., Dakin, Stephanie G., Snelling, Sarah J.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153485/
https://www.ncbi.nlm.nih.gov/pubmed/34054865
http://dx.doi.org/10.3389/fimmu.2021.676173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153485/
https://www.ncbi.nlm.nih.gov/pubmed/34054865
http://dx.doi.org/10.3389/fimmu.2021.676173

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