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Interleukin-17A Causes Osteoarthritis-Like Transcriptional Changes in Human Osteoarthritis-Derived Chondrocytes and Synovial Fibroblasts In Vitro
Increased interleukin (IL)-17A has been identified in joints affected by osteoarthritis (OA), but it is unclear how IL-17A, and its family members IL-17AF and IL-17F, can contribute to human OA pathophysiology. Therefore, we aimed to evaluate the gene expression and signalling pathway activation eff...
Autores principales: | Mimpen, Jolet Y., Baldwin, Mathew J., Cribbs, Adam P., Philpott, Martin, Carr, Andrew J., Dakin, Stephanie G., Snelling, Sarah J.B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153485/ https://www.ncbi.nlm.nih.gov/pubmed/34054865 http://dx.doi.org/10.3389/fimmu.2021.676173 |
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