Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice

Mitochondrial dysfunction is a key driver of inflammatory responses in human disease. However, it remains unclear whether alterations in mitochondria-innate immune cross-talk contribute to the pathobiology of mitochondrial disorders and aging. Using the polymerase gamma (POLG) mutator model of mitoc...

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Detalles Bibliográficos
Autores principales: Lei, Yuanjiu, Guerra Martinez, Camila, Torres-Odio, Sylvia, Bell, Samantha L., Birdwell, Christine E., Bryant, Joshua D., Tong, Carl W., Watson, Robert O., West, Laura Ciaccia, West, A. Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153723/
https://www.ncbi.nlm.nih.gov/pubmed/34039599
http://dx.doi.org/10.1126/sciadv.abe7548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153723/
https://www.ncbi.nlm.nih.gov/pubmed/34039599
http://dx.doi.org/10.1126/sciadv.abe7548

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