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Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Gambogic Acid against Endometrial Cancer

[Image: see text] Endometrial cancer (EC) is one of the three most common gynecological cancers in female groups. Gambogic acid (GA), a natural caged xanthone, exerts significantly antitumor effects on many cancers. However, its efficacy on EC and pharmacological mechanism of action remain marginal...

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Autores principales: Xia, Zhengxiang, Tang, Zhongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153951/
https://www.ncbi.nlm.nih.gov/pubmed/34056247
http://dx.doi.org/10.1021/acsomega.1c00696
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author Xia, Zhengxiang
Tang, Zhongyan
author_facet Xia, Zhengxiang
Tang, Zhongyan
author_sort Xia, Zhengxiang
collection PubMed
description [Image: see text] Endometrial cancer (EC) is one of the three most common gynecological cancers in female groups. Gambogic acid (GA), a natural caged xanthone, exerts significantly antitumor effects on many cancers. However, its efficacy on EC and pharmacological mechanism of action remain marginal up to now. This study suggested that GA had significant inhibitory effects on EC in vitro and in vivo, and no toxicity to normal cells or mice. In detail, GA suppressed cell proliferation, induced cell apoptosis, and cell cycle arrest at G(0)/G(1) stage, complied with the network pharmacology analysis, showed that the PI3K/Akt pathways were the most important signaling, and their protein and mRNA expression levels were confirmed by qRT-PCR and Western blot experiments. In all, our study first proved that GA could inhibit cell proliferation, induce cell apoptosis, and cell cycle arrest at G(0)/G(1) stage via the PI3K/Akt pathways, so GA would be a good therapy for EC.
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spelling pubmed-81539512021-05-27 Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Gambogic Acid against Endometrial Cancer Xia, Zhengxiang Tang, Zhongyan ACS Omega [Image: see text] Endometrial cancer (EC) is one of the three most common gynecological cancers in female groups. Gambogic acid (GA), a natural caged xanthone, exerts significantly antitumor effects on many cancers. However, its efficacy on EC and pharmacological mechanism of action remain marginal up to now. This study suggested that GA had significant inhibitory effects on EC in vitro and in vivo, and no toxicity to normal cells or mice. In detail, GA suppressed cell proliferation, induced cell apoptosis, and cell cycle arrest at G(0)/G(1) stage, complied with the network pharmacology analysis, showed that the PI3K/Akt pathways were the most important signaling, and their protein and mRNA expression levels were confirmed by qRT-PCR and Western blot experiments. In all, our study first proved that GA could inhibit cell proliferation, induce cell apoptosis, and cell cycle arrest at G(0)/G(1) stage via the PI3K/Akt pathways, so GA would be a good therapy for EC. American Chemical Society 2021-04-14 /pmc/articles/PMC8153951/ /pubmed/34056247 http://dx.doi.org/10.1021/acsomega.1c00696 Text en © 2021 The Authors. Published by American Chemical Society Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Xia, Zhengxiang
Tang, Zhongyan
Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Gambogic Acid against Endometrial Cancer
title Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Gambogic Acid against Endometrial Cancer
title_full Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Gambogic Acid against Endometrial Cancer
title_fullStr Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Gambogic Acid against Endometrial Cancer
title_full_unstemmed Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Gambogic Acid against Endometrial Cancer
title_short Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Gambogic Acid against Endometrial Cancer
title_sort network pharmacology analysis and experimental pharmacology study explore the mechanism of gambogic acid against endometrial cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153951/
https://www.ncbi.nlm.nih.gov/pubmed/34056247
http://dx.doi.org/10.1021/acsomega.1c00696
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