In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo

Proteasome-catalyzed peptide splicing (PCPS) of cancer-driving antigens could generate attractive neoepitopes to be targeted by T cell receptor (TCR)-based adoptive T cell therapy. Based on a spliced peptide prediction algorithm, TCRs were generated against putative KRAS(G12V)- and RAC2(P29L)-derive...

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Detalles Bibliográficos
Autores principales: Willimsky, Gerald, Beier, Christin, Immisch, Lena, Papafotiou, George, Scheuplein, Vivian, Goede, Andrean, Holzhütter, Hermann-Georg, Blankenstein, Thomas, Kloetzel, Peter M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154032/
https://www.ncbi.nlm.nih.gov/pubmed/33875134
http://dx.doi.org/10.7554/eLife.62019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154032/
https://www.ncbi.nlm.nih.gov/pubmed/33875134
http://dx.doi.org/10.7554/eLife.62019

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