Cargando…
In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo
Proteasome-catalyzed peptide splicing (PCPS) of cancer-driving antigens could generate attractive neoepitopes to be targeted by T cell receptor (TCR)-based adoptive T cell therapy. Based on a spliced peptide prediction algorithm, TCRs were generated against putative KRAS(G12V)- and RAC2(P29L)-derive...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154032/ https://www.ncbi.nlm.nih.gov/pubmed/33875134 http://dx.doi.org/10.7554/eLife.62019 |