A Plug-and-Play Platform for the Formation of Trifunctional Cysteine Bioconjugates that also Offers Control over Thiol Cleavability

[Image: see text] Linkers that enable the site-selective synthesis of chemically modified proteins are of great interest to the field of chemical biology. Homogenous bioconjugates often show advantageous pharmacokinetic profiles and consequently increased efficacy in vivo. Cysteine residues have bee...

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Detalles Bibliográficos
Autores principales: Bahou, Calise, Szijj, Peter A., Spears, Richard J., Wall, Archie, Javaid, Faiza, Sattikar, Afrah, Love, Elizabeth A., Baker, James R., Chudasama, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154211/
https://www.ncbi.nlm.nih.gov/pubmed/33710874
http://dx.doi.org/10.1021/acs.bioconjchem.1c00057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154211/
https://www.ncbi.nlm.nih.gov/pubmed/33710874
http://dx.doi.org/10.1021/acs.bioconjchem.1c00057

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