Exploring the Effect of Cyclization of Histamine H(1) Receptor Antagonists on Ligand Binding Kinetics

[Image: see text] There is an increasing interest in guiding hit optimization by considering the target binding kinetics of ligands. However, compared to conventional structure–activity relationships, structure–kinetics relationships have not been as thoroughly explored, even for well-studied archet...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zhiyong, Bosma, Reggie, Kuhne, Sebastiaan, van den Bor, Jelle, Garabitian, Wrej, Vischer, Henry F., Wijtmans, Maikel, Leurs, Rob, de Esch, Iwan J.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154229/
https://www.ncbi.nlm.nih.gov/pubmed/34056427
http://dx.doi.org/10.1021/acsomega.0c06358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154229/
https://www.ncbi.nlm.nih.gov/pubmed/34056427
http://dx.doi.org/10.1021/acsomega.0c06358

Ejemplares similares