Comprehensive Structural and Thermodynamic Analysis of Prefibrillar WT α-Synuclein and Its G51D, E46K, and A53T Mutants by a Combination of Small-Angle X-ray Scattering and Variational Bayesian Weighting

[Image: see text] The in solution synchrotron small-angle X-ray scattering SAXS technique has been used to investigate an intrinsically disordered protein (IDP) related to Parkinson’s disease, the α-synuclein (α-syn), in prefibrillar diluted conditions. SAXS experiments have been performed as a func...

Descripción completa

Detalles Bibliográficos
Autores principales: Moretti, Paolo, Mariani, Paolo, Ortore, Maria Grazia, Plotegher, Nicoletta, Bubacco, Luigi, Beltramini, Mariano, Spinozzi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154249/
https://www.ncbi.nlm.nih.gov/pubmed/32866007
http://dx.doi.org/10.1021/acs.jcim.0c00807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154249/
https://www.ncbi.nlm.nih.gov/pubmed/32866007
http://dx.doi.org/10.1021/acs.jcim.0c00807

Ejemplares similares