Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid–Base Catalysis

[Image: see text] Acid–base catalysis, which involves one or more proton transfer reactions, is a chemical mechanism commonly employed by many enzymes. The molecular basis for catalysis is often derived from structures determined at the optimal pH for enzyme activity. However, direct observation of...

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Detalles Bibliográficos
Autores principales: Wan, Qun, Bennett, Brad C., Wymore, Troy, Li, Zhihong, Wilson, Mark A., Brooks, Charles L., Langan, Paul, Kovalevsky, Andrey, Dealwis, Chris G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154319/
https://www.ncbi.nlm.nih.gov/pubmed/34055457
http://dx.doi.org/10.1021/acscatal.1c00417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154319/
https://www.ncbi.nlm.nih.gov/pubmed/34055457
http://dx.doi.org/10.1021/acscatal.1c00417

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