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Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid–Base Catalysis
[Image: see text] Acid–base catalysis, which involves one or more proton transfer reactions, is a chemical mechanism commonly employed by many enzymes. The molecular basis for catalysis is often derived from structures determined at the optimal pH for enzyme activity. However, direct observation of...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154319/ https://www.ncbi.nlm.nih.gov/pubmed/34055457 http://dx.doi.org/10.1021/acscatal.1c00417 |