Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

[Image: see text] Targeted protein degradation has emerged as a new paradigm to manipulate cellular proteostasis. Proteolysis-targeting chimeras (PROTACs) are bifunctional small molecules that recruit an E3 ligase to a target protein of interest, promoting its ubiquitination and subsequent degradati...

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Detalles Bibliográficos
Autores principales: Cotton, Adam D., Nguyen, Duy P., Gramespacher, Josef A., Seiple, Ian B., Wells, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154509/
https://www.ncbi.nlm.nih.gov/pubmed/33395526
http://dx.doi.org/10.1021/jacs.0c10008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154509/
https://www.ncbi.nlm.nih.gov/pubmed/33395526
http://dx.doi.org/10.1021/jacs.0c10008

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