Azidothymidine “Clicked” into 1,2,3-Triazoles: First Report on Carbonic Anhydrase–Telomerase Dual-Hybrid Inhibitors

[Image: see text] Cancer cells rely on the enzyme telomerase (EC 2.7.7.49) to promote cellular immortality. Telomerase inhibitors (i.e., azidothymidine) can represent promising antitumor agents, although showing high toxicity when administered alone. Better outcomes were observed within a multipharm...

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Detalles Bibliográficos
Autores principales: Berrino, Emanuela, Angeli, Andrea, Zhdanov, Dmitry D., Kiryukhina, Anna P., Milaneschi, Andrea, De Luca, Alessandro, Bozdag, Murat, Carradori, Simone, Selleri, Silvia, Bartolucci, Gianluca, Peat, Thomas S., Ferraroni, Marta, Supuran, Claudiu T., Carta, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154556/
https://www.ncbi.nlm.nih.gov/pubmed/32463228
http://dx.doi.org/10.1021/acs.jmedchem.0c00636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154556/
https://www.ncbi.nlm.nih.gov/pubmed/32463228
http://dx.doi.org/10.1021/acs.jmedchem.0c00636

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