Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A(2A) Receptor

[Image: see text] In this study, we determined the crystal structure of an engineered human adenosine A(2A) receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction between the partial agonist, belon...

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Detalles Bibliográficos
Autores principales: Amelia, Tasia, van Veldhoven, Jacobus P. D., Falsini, Matteo, Liu, Rongfang, Heitman, Laura H., van Westen, Gerard J. P., Segala, Elena, Verdon, Grégory, Cheng, Robert K. Y., Cooke, Robert M., van der Es, Daan, IJzerman, Adriaan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154574/
https://www.ncbi.nlm.nih.gov/pubmed/33764785
http://dx.doi.org/10.1021/acs.jmedchem.0c01856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154574/
https://www.ncbi.nlm.nih.gov/pubmed/33764785
http://dx.doi.org/10.1021/acs.jmedchem.0c01856

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