Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities

[Image: see text] In this study, we report the design and synthesis of a series of novel thiophene-arylamide compounds derived from the noncovalent decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1) inhibitor TCA1 through a structure-based scaffold hopping strategy. Systematic optimization of the...

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Detalles Bibliográficos
Autores principales: Wang, Pengxu, Batt, Sarah M., Wang, Bin, Fu, Lei, Qin, Rongfei, Lu, Yu, Li, Gang, Besra, Gurdyal S., Huang, Haihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154581/
https://www.ncbi.nlm.nih.gov/pubmed/33852302
http://dx.doi.org/10.1021/acs.jmedchem.1c00263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154581/
https://www.ncbi.nlm.nih.gov/pubmed/33852302
http://dx.doi.org/10.1021/acs.jmedchem.1c00263

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