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The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities

[Image: see text] Over the years, researchers in drug discovery have taken advantage of the use of privileged structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many natural products, and it has been widely exploited by medicinal chemists to develop compounds tailo...

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Detalles Bibliográficos
Autores principales: Robello, Marco, Barresi, Elisabetta, Baglini, Emma, Salerno, Silvia, Taliani, Sabrina, Settimo, Federico Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154582/
https://www.ncbi.nlm.nih.gov/pubmed/33764065
http://dx.doi.org/10.1021/acs.jmedchem.0c01808