Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53

Ovarian cancer (OvCA) remains one of the most devastating malignancies, but treatment options are still limited. We report that amphiregulin (AREG) can serve as an effective and safe pharmacological target in a syngeneic murine model. AREG is highly abundant in abdominal fluids of patients with adva...

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Detalles Bibliográficos
Autores principales: Lindzen, Moshit, Ghosh, Soma, Noronha, Ashish, Drago, Diana, Nataraj, Nishanth Belugali, Leitner, Orith, Carvalho, Silvia, Zmora, Einav, Sapoznik, Stav, Shany, Keren Bahar, Levanon, Keren, Aderka, Dan, Ramírez, Belinda Sánchez, Dahlhoff, Maik, McNeish, Iain, Yarden, Yosef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154589/
https://www.ncbi.nlm.nih.gov/pubmed/33941851
http://dx.doi.org/10.1038/s41388-021-01784-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154589/
https://www.ncbi.nlm.nih.gov/pubmed/33941851
http://dx.doi.org/10.1038/s41388-021-01784-8

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