Synthesis, antibacterial action, and ribosome inhibition of deoxyspectinomycins

Spectinomycin, an aminocyclitol antibiotic, is subject to inactivation by aminoglycoside modifying enzymes (AMEs) through adenylylation or phosphorylation of the 6-hydroxy group position. In this study, the effects of deoxygenation of the 2- and 6-hydroxy group positions on the spectinomycin actinam...

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Detalles Bibliográficos
Autores principales: Dharuman, Suresh, Wilt, Laura A., Liu, Jiuyu, Reeve, Stephanie M., Thompson, Carl W., Elmore, John M., Shcherbakov, Dimitri, Lee, Robin B., Böttger, Erik C., Lee, Richard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154590/
https://www.ncbi.nlm.nih.gov/pubmed/33504919
http://dx.doi.org/10.1038/s41429-021-00408-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154590/
https://www.ncbi.nlm.nih.gov/pubmed/33504919
http://dx.doi.org/10.1038/s41429-021-00408-3

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