ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab

The clinical performance of the therapeutic monoclonal antibody trastuzumab in the treatment of ErbB2-positive unresectable gastric cancer (GC) is severely hampered by the emergence of molecular resistance. Trastuzumab’s target epitope is localized within the extracellular domain of the oncogenic ce...

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Detalles Bibliográficos
Autores principales: Duarte, Henrique O., Rodrigues, Joana G., Gomes, Catarina, Hensbergen, Paul J., Ederveen, Agnes L. Hipgrave, de Ru, Arnoud H., Mereiter, Stefan, Polónia, António, Fernandes, Elisabete, Ferreira, José A., van Veelen, Peter A., Santos, Lúcio L., Wuhrer, Manfred, Gomes, Joana, Reis, Celso A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154592/
https://www.ncbi.nlm.nih.gov/pubmed/33947960
http://dx.doi.org/10.1038/s41388-021-01801-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154592/
https://www.ncbi.nlm.nih.gov/pubmed/33947960
http://dx.doi.org/10.1038/s41388-021-01801-w

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