TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap

Chaperones Tapasin and TAP-binding protein related (TAPBPR) perform the important functions of stabilizing nascent MHC-I molecules (chaperoning) and selecting high-affinity peptides in the MHC-I groove (editing). While X-ray and cryo-EM snapshots of MHC-I in complex with TAPBPR and Tapasin, respecti...

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Detalles Bibliográficos
Autores principales: McShan, Andrew C., Devlin, Christine A., Morozov, Giora I., Overall, Sarah A., Moschidi, Danai, Akella, Neha, Procko, Erik, Sgourakis, Nikolaos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154891/
https://www.ncbi.nlm.nih.gov/pubmed/34039964
http://dx.doi.org/10.1038/s41467-021-23225-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154891/
https://www.ncbi.nlm.nih.gov/pubmed/34039964
http://dx.doi.org/10.1038/s41467-021-23225-6

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