Resistance of bone marrow stroma to genotoxic preconditioning is determined by p53

Transplantation of bone marrow (BM) is made possible by the differential sensitivity of its stromal and hematopoietic components to preconditioning by radiation and/or chemotherapeutic drugs. These genotoxic treatments eliminate host hematopoietic precursors by inducing p53-mediated apoptosis but ke...

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Detalles Bibliográficos
Autores principales: Fedtsova, Natalia, Komarova, Elena A., Greene, Kellee F., Novototskaya, Liliya R., Molodtsov, Ivan, Brackett, Craig M., Strom, Evguenia, Gleiberman, Anatoli S., Shakhov, Alexander N., Gudkov, Andrei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154997/
https://www.ncbi.nlm.nih.gov/pubmed/34039962
http://dx.doi.org/10.1038/s41419-021-03824-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154997/
https://www.ncbi.nlm.nih.gov/pubmed/34039962
http://dx.doi.org/10.1038/s41419-021-03824-3

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