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Cooperative inhibition of SNARE-mediated vesicle fusion by α-synuclein monomers and oligomers

The primary hallmark of Parkinson's disease (PD) is the generation of Lewy bodies of which major component is α-synuclein (α-Syn). Because of increasing evidence of the fundamental roles of α-Syn oligomers in disease progression, α-Syn oligomers have become potential targets for therapeutic int...

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Detalles Bibliográficos
Autores principales: Yoo, Gyeongji, Yeou, Sanghun, Son, Jung Bae, Shin, Yeon-Kyun, Lee, Nam Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155056/
https://www.ncbi.nlm.nih.gov/pubmed/34040104
http://dx.doi.org/10.1038/s41598-021-90503-0