Dephosphorylation Passivates the Seeding Activity of Oligomeric Tau Derived From Alzheimer’s Brain

Accumulation of intracellular neurofibrillary tangles (NFTs), which are constituted of abnormally phosphorylated tau, is one of the neuropathological hallmarks of Alzheimer’s disease (AD). The oligomeric aggregates of tau in AD brain (AD O-tau) are believed to trigger NFT spreading by seeding normal...

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Detalles Bibliográficos
Autores principales: Wu, Ruozhen, Li, Longfei, Shi, Ruirui, Zhou, Yan, Jin, Nana, Gu, Jianlan, Tung, Yunn Chyn, Liu, Fei, Chu, Dandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155256/
https://www.ncbi.nlm.nih.gov/pubmed/34054426
http://dx.doi.org/10.3389/fnmol.2021.631833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155256/
https://www.ncbi.nlm.nih.gov/pubmed/34054426
http://dx.doi.org/10.3389/fnmol.2021.631833

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