Increased Plasma Level of 24S-Hydroxycholesterol and Polymorphism of CYP46A1 SNP (rs754203) Are Associated With Mild Cognitive Impairment in Patients With Type 2 Diabetes

BACKGROUND: Abnormal cholesterol metabolism is common in type 2 diabetes mellitus (T2DM) and causes dementia. Cholesterol 24S-hydroxylase (CYP46A1) converts cholesterol into 24S-hydroxycholesterol (24-OHC) and maintains cholesterol homeostasis in the brain. OBJECTIVE: This study aimed to investigate...

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Detalles Bibliográficos
Autores principales: Shi, Jijing, Jia, Jianhong, Tian, Sai, Zhang, Haoqiang, An, Ke, Zhu, Wenwen, Cao, Wuyou, Yuan, Yang, Wang, Shaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155290/
https://www.ncbi.nlm.nih.gov/pubmed/34054500
http://dx.doi.org/10.3389/fnagi.2021.619916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155290/
https://www.ncbi.nlm.nih.gov/pubmed/34054500
http://dx.doi.org/10.3389/fnagi.2021.619916

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