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Cytosolic Delivery of Argininosuccinate Synthetase Using a Cell-Permeant Miniature Protein
[Image: see text] Citrullinemia type I (CTLN-I) results from the absence or deficiency of argininosuccinate synthetase (AS), a 46 kDa enzyme that acts in the cytosol of hepatocytes to convert aspartic acid and citrulline into argininosuccinic acid. AS is an essential component of the urea cycle, and...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155463/ https://www.ncbi.nlm.nih.gov/pubmed/34056094 http://dx.doi.org/10.1021/acscentsci.0c01603 |