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Cytosolic Delivery of Argininosuccinate Synthetase Using a Cell-Permeant Miniature Protein

[Image: see text] Citrullinemia type I (CTLN-I) results from the absence or deficiency of argininosuccinate synthetase (AS), a 46 kDa enzyme that acts in the cytosol of hepatocytes to convert aspartic acid and citrulline into argininosuccinic acid. AS is an essential component of the urea cycle, and...

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Detalles Bibliográficos
Autores principales:	Knox, Susan L., Wissner, Rebecca, Piszkiewicz, Samantha, Schepartz, Alanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155463/ https://www.ncbi.nlm.nih.gov/pubmed/34056094 http://dx.doi.org/10.1021/acscentsci.0c01603

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