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Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization
[Image: see text] Covalent ligands are a versatile class of chemical probes and drugs that can target noncanonical sites on proteins and display differentiated pharmacodynamic properties. Chemical proteomic methods have been introduced that leverage electrophilic fragments to globally profile the co...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155467/ https://www.ncbi.nlm.nih.gov/pubmed/34056091 http://dx.doi.org/10.1021/acscentsci.0c01336 |