Salidroside Inhibits CCl(4)-Induced Liver Fibrosis in Mice by Reducing Activation and Migration of HSC Induced by Liver Sinusoidal Endothelial Cell-Derived Exosomal SphK1

Sphingosine kinase 1 (SphK1)/Sphingosine-1-phosphate (S1P)/S1PRs signaling pathway is known to involve the advancement of liver fibrosis. Exosomal SphK1 promotes hepatic stellate cells (HSC) migration. Salidroside (Sal) inhibits liver fibrosis, but its mechanism is yet to be elucidated. This study w...

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Detalles Bibliográficos
Autores principales: Ye, Qiannan, Zhou, Yang, Zhao, Changqing, Xu, Lieming, Ping, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155673/
https://www.ncbi.nlm.nih.gov/pubmed/34054552
http://dx.doi.org/10.3389/fphar.2021.677810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155673/
https://www.ncbi.nlm.nih.gov/pubmed/34054552
http://dx.doi.org/10.3389/fphar.2021.677810

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