Cargando…

Acute acetate administration increases endogenous opioid levels in the human brain: A [(11)C]carfentanil molecular imaging study

INTRODUCTION: A recent study has shown that acetate administration leads to a fourfold increase in the transcription of proopiomelanocortin (POMC) mRNA in the hypothalamus. POMC is cleaved to peptides, including β-endorphin, an endogenous opioid (EO) agonist that binds preferentially to the µ-opioid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ashok, Abhishekh H, Myers, Jim, Frost, Gary, Turton, Samuel, Gunn, Roger N, Passchier, Jan, Colasanti, Alessandro, Marques, Tiago Reis, Nutt, David, Lingford-Hughes, Anne, Howes, Oliver D, Rabiner, Eugenii A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2021
Materias:	Short Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155733/ https://www.ncbi.nlm.nih.gov/pubmed/33406950 http://dx.doi.org/10.1177/0269881120965912

Ejemplares similares

Reduced mu opioid receptor availability in schizophrenia revealed with [(11)C]-carfentanil positron emission tomographic Imaging
por: Ashok, Abhishekh H., et al.
Publicado: (2019)

Reward processing in schizophrenia and its relation to Mu opioid receptor availability and negative symptoms: A [(11)C]-carfentanil PET and fMRI study
por: Shatalina, Ekaterina, et al.
Publicado: (2023)

O5.5. THE NEUROBIOLOGY OF NEGATIVE SYMPTOMS IN SCHIZOPHRENIA: MULTI-MODAL PET AND FMRI FINDINGS
por: Howes, Oliver, et al.
Publicado: (2020)

Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals
por: Turton, Samuel, et al.
Publicado: (2018)

Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers
por: Mick, Inge, et al.
Publicado: (2016)

GABA-A receptor differences in schizophrenia: a positron emission tomography study using [(11)C]Ro154513
por: Marques, Tiago Reis, et al.
Publicado: (2020)

First evaluation of PET-based human biodistribution and radiation dosimetry of (11)C-BU99008, a tracer for imaging the imidazoline(2) binding site
por: Venkataraman, Ashwin V., et al.
Publicado: (2018)

Adenosine A(2A) receptor in schizophrenia: an in vivo brain PET imaging study
por: Marques, Tiago Reis, et al.
Publicado: (2021)

The Synthesis of Biphasic Metabolites of Carfentanil
por: Wang, Junchang, et al.
Publicado: (2023)

Specific and non-specific binding of a tracer for the translocator-specific protein in schizophrenia: an [11C]-PBR28 blocking study
por: Marques, Tiago Reis, et al.
Publicado: (2021)

Carfentanil Outbreak — Florida, 2016–2017
por: Delcher, Chris, et al.
Publicado: (2020)

Association of Law Enforcement Seizures of Heroin, Fentanyl, and Carfentanil With Opioid Overdose Deaths in Ohio, 2014-2017
por: Zibbell, Jon E., et al.
Publicado: (2019)

Assessment of naloxone as a therapeutic for inhaled carfentanil in the ferret
por: McCranor, Bryan J., et al.
Publicado: (2020)

G protein‐biased kratom‐alkaloids and synthetic carfentanil‐amide opioids as potential treatments for alcohol use disorder
por: Gutridge, Anna M., et al.
Publicado: (2020)

Trends in opioid overdose fatalities in Cuyahoga County, Ohio: Multi-drug mixtures, the African-American community and carfentanil
por: Bhullar, Manreet K., et al.
Publicado: (2022)

Boosting the diagnostic power of amyloid-β PET using a data-driven spatially informed classifier for decision support
por: Venkataraman, Ashwin V., et al.
Publicado: (2021)

Carfentanil Blood Concentrations in Impaired Driving Investigations in Ontario, Canada
por: Wallage, H Rachelle, et al.
Publicado: (2022)

[(11)C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue
por: Sun, Lihua, et al.
Publicado: (2022)

DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats
por: Sharma, Puneet K., et al.
Publicado: (2020)

Endogenous dopamine release in the human brain as a pharmacodynamic biomarker: evaluation of the new GPR139 agonist TAK-041 with [(11)C]PHNO PET
por: Rabiner, Eugenii A., et al.
Publicado: (2021)

Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development
por: McCluskey, Stuart P., et al.
Publicado: (2019)

Regional Brain [(11)C]carfentanil Binding Following Tobacco Smoking
por: Domino, Edward F, et al.
Publicado: (2015)

Fentanyls continue to replace heroin in the drug arena: the cases of ocfentanil and carfentanil
por: Misailidi, Nektaria, et al.
Publicado: (2017)

Activity-Based Detection and Bioanalytical Confirmation of a Fatal Carfentanil Intoxication
por: Cannaert, Annelies, et al.
Publicado: (2018)

Elevating Endogenous GABA Levels with GAT-1 Blockade Modulates Evoked but Not Induced Responses in Human Visual Cortex
por: Muthukumaraswamy, Suresh D, et al.
Publicado: (2013)

Evidence for GABA‐A receptor dysregulation in gambling disorder: correlation with impulsivity
por: Mick, Inge, et al.
Publicado: (2016)

The Effects of Intramuscular Naloxone Dose on Mu Receptor Displacement of Carfentanil in Rhesus Monkeys
por: Scott, Peter J. H., et al.
Publicado: (2020)

O11.3. SYNAPTIC MARKER PROTEIN SV2A IS REDUCED IN SCHIZOPHRENIA IN VIVO AND UNAFFECTED BY ANTIPSYCHOTICS IN RATS
por: Chika Onwordi, Ellis, et al.
Publicado: (2020)

The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study
por: Onwordi, Ellis Chika, et al.
Publicado: (2021)

Quantification of human brain PDE4 occupancy by GSK356278: A [(11)C](R)-rolipram PET study
por: van der Aart, Jasper, et al.
Publicado: (2017)

Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies
por: Marques, Tiago Reis, et al.
Publicado: (2019)

Naloxone’s dose-dependent displacement of [(11)C]carfentanil and duration of receptor occupancy in the rat brain
por: Kang, Yeona, et al.
Publicado: (2022)

An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity that Reverses Carfentanil-Induced Respiratory Depression
por: Eubanks, Lisa M., et al.
Publicado: (2023)

Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
por: Onwordi, Ellis Chika, et al.
Publicado: (2020)

Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO)()
por: Colasanti, Alessandro, et al.
Publicado: (2013)

The histamine system and cognitive function: An in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia
por: Arumuham, Atheeshaan, et al.
Publicado: (2023)

Identifying improved TSPO PET imaging probes through biomathematics: The impact of multiple TSPO binding sites in vivo
por: Guo, Qi, et al.
Publicado: (2012)

An evaluation of the brain distribution of [(11)C]GSK1034702, a muscarinic-1 (M(1)) positive allosteric modulator in the living human brain using positron emission tomography
por: Ridler, Khanum, et al.
Publicado: (2014)

Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies
por: Ashok, Abhishekh H., et al.
Publicado: (2019)

Contribution of the μ‐opioid receptor system to affective disorders in temporal lobe epilepsy: A bidirectional relationship?
por: Sone, Daichi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8vugipcdifpcg35ercv568qveb