Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

While young blood can restore many aged tissues, its effects on the aged blood system itself and old hematopoietic stem cells (HSCs) have not been determined. Here, we used transplantation, parabiosis, plasma transfer, exercise, calorie restriction, and aging mutant mice to understand the effects of...

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Detalles Bibliográficos
Autores principales: Ho, Theodore T., Dellorusso, Paul V., Verovskaya, Evgenia V., Bakker, Sietske T., Flach, Johanna, Smith, Lucas K., Ventura, Patrick B., Lansinger, Olivia M., Hérault, Aurélie, Zhang, Si Yi, Kang, Yoon-A, Mitchell, Carl A., Villeda, Saul A., Passegué, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155813/
https://www.ncbi.nlm.nih.gov/pubmed/34032859
http://dx.doi.org/10.1084/jem.20210223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155813/
https://www.ncbi.nlm.nih.gov/pubmed/34032859
http://dx.doi.org/10.1084/jem.20210223

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