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Rely on Each Other: DNA Binding Cooperativity Shapes p53 Functions in Tumor Suppression and Cancer Therapy
SIMPLE SUMMARY: p53 is a DNA-binding protein that activates hundreds of genes, which act concertedly to suppress the development, expansion, and spreading of cancer cells. The remarkable tumor suppressive activity relies on p53′s ability to bind DNA not as a single molecule, but in a cooperative man...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155944/ https://www.ncbi.nlm.nih.gov/pubmed/34067731 http://dx.doi.org/10.3390/cancers13102422 |