Structural Insights into the Interaction of Filovirus Glycoproteins with the Endosomal Receptor Niemann-Pick C1: A Computational Study

Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the endosomal receptor Niemann-Pick C1 (NPC1) protei...

Descripción completa

Detalles Bibliográficos
Autores principales: Igarashi, Manabu, Hirokawa, Takatsugu, Takadate, Yoshihiro, Takada, Ayato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156010/
https://www.ncbi.nlm.nih.gov/pubmed/34069246
http://dx.doi.org/10.3390/v13050913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156010/
https://www.ncbi.nlm.nih.gov/pubmed/34069246
http://dx.doi.org/10.3390/v13050913

Ejemplares similares