Design, Synthesis, and Anticancer Screening for Repurposed Pyrazolo[3,4-d]pyrimidine Derivatives on Four Mammalian Cancer Cell Lines

The present study reports the synthesis of new purine bioisosteres comprising a pyrazolo[3,4-d]pyrimidine scaffold linked to mono-, di-, and trimethoxy benzylidene moieties through hydrazine linkages. First, in silico docking experiments of the synthesized compounds against Bax, Bcl-2, Caspase-3, Ki...

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Detalles Bibliográficos
Autores principales: Othman, Eman M., Bekhit, Amany A., Anany, Mohamed A., Dandekar, Thomas, Ragab, Hanan M., Wahid, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156061/
https://www.ncbi.nlm.nih.gov/pubmed/34065773
http://dx.doi.org/10.3390/molecules26102961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156061/
https://www.ncbi.nlm.nih.gov/pubmed/34065773
http://dx.doi.org/10.3390/molecules26102961

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